Marijuana and Schizophrenia

Written by David Frum on Tuesday January 11, 2011

My weekend blogpost noting the link between schizophrenia and heavy marijuana smoking evoked a certain (ie large) amount of derision.

My weekend blogpost noting the link between schizophrenia and heavy marijuana smoking evoked a certain (ie large) amount of derision. The libertarian spirit of the Internet does not like to hear bad news about prohibited drugs.

But the evidence that marijuana can trigger psychosis among those genetically predisposed to schizophrenia is strong. This site does a good round up of the (disturbing) literature:


Most Recent Scientific Research on Schizophrenia and Cannabis:

span style="color: #2222aa;">Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases.< Br J Psychiatry. 2005 Dec;187:510-5

span style="color: #2222aa;">Toward a world consensus on prevention of schizophrenia.<
Dialogues Clin Neurosci. 2005;7(1):53-67.

span style="color: #2222aa;">Risk for schizophrenia--broadening the concepts, pushing back the boundaries.<
Schizophr Res. 2005 Nov 1;79(1):5-13.

span style="color: #2222aa;">The environment and schizophrenia: the role of cannabis use.<
Schizophr Bull. 2005 Jul;31(3):608-12. Epub 2005 Jun 23.

span style="color: #2222aa;">Predictors of schizophrenia--a review.<
Br Med Bull. 2005 Jun 9;73:1-15. Print 2005.

span style="color: #2222aa;">Cannabis as a risk factor for psychosis: systematic review.<
J Psychopharmacol. 2005 Mar;19(2):187-94.

span style="color: #2222aa;">Cannabis use prior to first onset psychosis predicts spared neurocognition at 10-year follow-up.<
Schizophr Res. 2005 Jun 1;75(1):135-7.

span style="color: #2222aa;">[Acute and chronic cognitive disorders caused by cannabis use]<
Rev Prat. 2005 Jan 15;55(1):23-6; discussion 27-9. French.

span style="color: #2222aa;">Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.<
Biol Psychiatry. 2005 Mar 15;57(6):594-608.

span style="color: #2222aa;">Cannabis use and psychotic disorders: an update.<
Drug Alcohol Rev. 2004 Dec;23(4):433-43. Review.

span style="color: #2222aa;">Is cannabis an anti-antipsychotic? The experience in psychiatric intensive care.<
Hum Psychopharmacol. 2005 Apr;20(3):207-10.

span style="color: #2222aa;">Cannabis and risk of psychosis.<
Swiss Med Wkly. 2004 Nov 13;134(45-46):659-63. Review.

span style="color: #2222aa;">[Cannabis can double the risk of schizophrenia. Increasing but still controversial knowledge of the psychological effects of the drug]<
Lakartidningen. 2004 Oct 7;101(41):3126-7. Swedish.

span style="color: #2222aa;">Is the party over? Cannabis and juvenile psychiatric disorder: the past 10 years.<
J Am Acad Child Adolesc Psychiatry. 2004 Oct;43(10):1194-205. Review.

span style="color: #2222aa;">Adverse effects of cannabis on health: an update of the literature since 1996.<
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63. Review.

span style="color: #2222aa;">Cannabis use and risk of psychosis: an etiological link?<
Epidemiol Psichiatr Soc. 2004 Apr-Jun;13(2):113-9. Review.

span style="color: #2222aa;">[Cannabis and schizophrenia. From euphoria to psychosis]<
Rev Med Liege. 2004 Feb;59(2):98-103. French.

span style="color: #2222aa;">Heavy cannabis users seeking treatment- prevalence of psychiatric disorders.<
Soc Psychiatry Psychiatr Epidemiol. 2004 Feb;39(2):97-105.

span style="color: #2222aa;">Cannabis use and the risk of later schizophrenia: a review.<
Addiction. 2004 Apr;99(4):425-30. Review.

span style="color: #2222aa;">Cannabis use and psychosis<.Drug Alcohol Rev. 1998 Dec;17(4):433-44.

Cannabis use and age at onset of schizophrenia.
Am J Psychiatry. 2004 Mar;161(3):501-6.

span style="color: #2222aa;">Causal association between cannabis and psychosis: examination of the evidence.<
Br J Psychiatry. 2004 Feb;184:110-7. Review.

span style="color: #2222aa;">[Cannabis use as a probable causative factor in the later development of schizophrenia]<
Ned Tijdschr Geneeskd. 2003 Nov 1;147(44):2178-83. Dutch.

span style="color: #2222aa;">[Use of cannabis in adolescence and risk of schizophrenia]<
Rev Bras Psiquiatr. 2003 Sep;25(3):131-2. Portuguese.

span style="color: #2222aa;">Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study.<
BMJ. 2002 Nov 23;325(7374):1212-3. No abstract available.

span style="color: #2222aa;">[Is there a temporal correlation between substance abuse and psychosis in adolescents?]<
Z Kinder Jugendpsychiatr Psychother. 2002 May;30(2):97-103. German.

span style="color: #2222aa;">Cannabis and psychosis.<
Curr Psychiatry Rep. 2002 Jun;4(3):191-6. Review.

span style="color: #2222aa;">Cannabis-induced psychosis: a cross-sectional comparison with acute schizophrenia.<
Acta Psychiatr Scand. 2002 Mar;105(3):173-8.

span style="color: #2222aa;">Cannabis and schizophrenia: a longitudinal study of cases treated in Stockholm County<

span style="color: #2222aa;">Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study<

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